PPIF Antibody

Datasheet

Code	CSB-PA903914
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA903914(PPIF Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA903914(PPIF Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA903914(PPIF Antibody) at dilution 1/675, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P30405

Target Names

PPIF

Alternative Names

Cyclophilin 3 antibody; cyclophilin D antibody; Cyclophilin F antibody; Cyp D antibody; CyP M antibody; CyP-D antibody; CyP-M antibody; CYP3 antibody; CypD antibody; hCyP3 antibody; mitochondrial antibody; Mitochondrial cyclophilin antibody; Peptidyl prolyl cis trans isomerase, mitochondral antibody; Peptidyl-prolyl cis-trans isomerase F antibody; Peptidyl-prolyl cis-trans isomerase F, mitochondrial antibody; Peptidylprolyl isomerase F (cyclophilin F) antibody; Peptidylprolyl isomerase F antibody; PPIase antibody; PPIase F antibody; Ppif antibody; PPIF_HUMAN antibody; Rotamase antibody; Rotamase F antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human PPIF

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:100-1:300

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Gene References into Functions

Cyclophilin D protects cell from cell death. PMID: 12077116
There was increased [Ca(2+)](c), [Ca(2+)](m), mCICR, MPTP opening, and expression of cyclophilin D and decreased DeltaPsim in POAG TM cells compared with control cells. PMID: 18614807

Subcellular Location

Mitochondrion matrix.

Protein Families

Cyclophilin-type PPIase family

Database Links

HGNC: 9259

OMIM: 604486

KEGG: hsa:10105

STRING: 9606.ENSP00000225174

UniGene: Hs.381072

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway cGMP-PKG signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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