PPM1H Antibody, Biotin conjugated

Code CSB-PA892345LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PPM1H Polyclonal antibody
Uniprot No.
Target Names
PPM1H
Alternative Names
PPM1H antibody; ARHCL1 antibody; KIAA1157 antibody; URCC2 antibody; Protein phosphatase 1H antibody; EC 3.1.3.16 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein phosphatase 1H protein (73-289AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
Gene References into Functions
  1. PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer PMID: 27599670
  2. PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. PMID: 24732009
  3. Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. PMID: 22586611
  4. PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein. PMID: 18059182
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
PP2C family
Database Links

HGNC: 18583

OMIM: 616016

KEGG: hsa:57460

UniGene: Hs.435479

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