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PPM1H Antibody, FITC conjugated

Datasheet
Code CSB-PA892345LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PPM1H Polyclonal antibody
Uniprot No.
Q9ULR3
Target Names
PPM1H
Alternative Names
PPM1H antibody; ARHCL1 antibody; KIAA1157 antibody; URCC2 antibody; Protein phosphatase 1H antibody; EC 3.1.3.16 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein phosphatase 1H protein (73-289AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PPM1H Antibodies

PPM1H Proteins

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Target Background

Function
Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
Gene References into Functions
  1. PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer PMID: 27599670
  2. PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. PMID: 24732009
  3. Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. PMID: 22586611
  4. PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein. PMID: 18059182
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
PP2C family
Database Links

HGNC: 18583

OMIM: 616016

KEGG: hsa:57460

UniGene: Hs.435479

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