PPM1H Antibody

Code CSB-PA892345LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA892345LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA892345LA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA892345LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Western Blot
    Positive WB detected in: Mouse stomach tissue, Mouse kidney tissue, Mouse skeletal muscle tissue
    All lanes: PPM1H antibody at 3.2μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 57 kDa
    Observed band size: 57 kDa

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PPM1H Polyclonal antibody
Uniprot No. Q9ULR3
Target Names PPM1H
Alternative Names PPM1H antibody; ARHCL1 antibody; KIAA1157 antibody; URCC2 antibody; Protein phosphatase 1H antibody; EC 3.1.3.16 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Protein phosphatase 1H protein (73-289AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:2000-1:10000
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
Gene References into Functions
  1. PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer PMID: 27599670
  2. PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. PMID: 24732009
  3. Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. PMID: 22586611
  4. PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein. PMID: 18059182
Subcellular Location Nucleus, Cytoplasm
Protein Families PP2C family
Database Links

HGNC: 18583

OMIM: 616016

KEGG: hsa:57460

UniGene: Hs.435479

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