PPM1K Antibody

Datasheet

Code	CSB-PA822697LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: A549 whole cell lysate, Mouse skeletal muscle tissue All lanes: PPM1K antibody at 2.7µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 41, 26, 17 kDa Observed band size: 41 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822697LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PPM1K Polyclonal antibody

Uniprot No.

Q8N3J5

Target Names

PPM1K

Alternative Names

BDP antibody; mitochondrial antibody; MSUDMV antibody; PP2C domain containing protein phosphatase 1K antibody; PP2C domain-containing protein phosphatase 1K antibody; PP2C kappa antibody; PP2C like mitochondrial protein antibody; PP2C type mitochondrial phosphoprotein phosphatase antibody; PP2C-kappa antibody; PP2C-like mitochondrial protein antibody; PP2C-type mitochondrial phosphoprotein phosphatase antibody; PP2Ckappa antibody; PP2CM antibody; PPM1K antibody; PPM1K_HUMAN antibody; Protein phosphatase 1K antibody; Protein phosphatase 1K; mitochondrial antibody; Protein phosphatase 2C isoform kappa antibody; Protein phosphatase Mg2+/Mn2+ dependent 1K antibody; PTMP antibody; UG0882E07 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Protein phosphatase 1K, mitochondrial protein (30-372AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PPM1K Antibody (Product code: CSB-PA822697LA01HU) is Non-conjugated. For PPM1K Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA822697LB01HU	PPM1K Antibody, HRP conjugated	ELISA
FITC	CSB-PA822697LC01HU	PPM1K Antibody, FITC conjugated
Biotin	CSB-PA822697LD01HU	PPM1K Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.

Gene References into Functions

Branched chain amino acids related genetic variant rs1440581 was associated with an increased risk of incident T2 Diabetes in a Chinese population. This variant might modify effect of weight gain on development in Insulin resistance. PMID: 29855804
PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes. PMID: 28768654
miR-204 and miR-211 directly repress PPM1K expression via 3'UTR. PMID: 26592513
Overweight people with the C allele of the branched-chain amino acid/aromatic amino acid ratio-associated variant rs1440581 may benefit less in weight loss and improved insulin sensitivity than those without it on a energy-restricted high-fat diet. PMID: 23446828
The 2.4 A PP2Cm structure reveals a central beta-sandwich with two bound metal ions in the active-site cleft. PMID: 22291014
A novel member of human protein phosphatase 2C gene family named PP2Ckappa was isolated from a human fetal brain cDNA library. PMID: 16685424
The cloned phosphatase has a mitochondrial leader sequence and its amino acid sequence places it in the PP2C family like two known mitochondrial phosphatases. PMID: 17336929

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Involvement in disease

Maple syrup urine disease, mild variant (MSUDMV)

Subcellular Location

Mitochondrion matrix.

Protein Families

PP2C family

Database Links

HGNC: 25415

OMIM: 611065

KEGG: hsa:152926

STRING: 9606.ENSP00000295908

UniGene: Hs.43744

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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