PPP2R5C Antibody

Code CSB-PA619761ESR2HU
Size US$299 How to order?
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA619761ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PPP2R5C Polyclonal antibody
Uniprot No. Q13362
Target Names PPP2R5C
Alternative Names 2A5G_HUMAN antibody; B' alpha regulatory subunit antibody; B56G antibody; KIAA0044 antibody; MGC23064 antibody; PP2A B subunit B' gamma isoform antibody; PP2A B subunit B56 gamma isoform antibody; PP2A B subunit isoform B' gamma antibody; PP2A B subunit isoform B''-gamma antibody; PP2A B subunit isoform B56-gamma antibody; PP2A B subunit isoform PR61-gamma antibody; PP2A B subunit isoform R5-gamma antibody; PP2A B subunit PR61 gamma isoform antibody; PP2A B subunit R5 gamma isoform antibody; Ppp2r5c antibody; PR61G antibody; Protein phosphatase 2 regulatory subunit B (B56) gamma isoform antibody; Protein phosphatase 2 regulatory subunit B' gamma antibody; Protein phosphatase 2; regulatory subunit B'; gamma isoform antibody; Renal carcinoma antigen NY REN 29 antibody; Renal carcinoma antigen NY-REN-29 antibody; Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform protein (1-320AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Gene References into Functions
  1. PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma. PMID: 26986830
  2. our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state. PMID: 26440364
  3. propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF, AKT2, AKT3, NFKB2 and STAT3 genes PMID: 25888193
  4. Differential expression of the transcripts PPP2R5C connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID: 25884766
  5. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase. PMID: 25512391
  6. Data indicate that the regulatory PP2A subunit B56gamma mediates suppression of NF-kappaB resulting in increased NF-kappaB target gene expression in T cells. PMID: 24719332
  7. Results show that mutations lost B56gamma tumor-suppressive activity by two distinct mechanisms: one is by disrupting interactions with the PP2A AC core and the other with B56gamma-PP2A substrates (p53 and unknown proteins). PMID: 23723076
  8. PPP2R5C-siRNA treatment altered gene expression profiles in malignant T cells PMID: 23941244
  9. structural insight into the PP2A holoenzyme assembly and emphasizes the importance of HEAT repeat 1 in B56gamma-PP2A tumor-suppressive function PMID: 22315229
  10. Overexpression of PPP2R5C in T-cell malignancy as well as in myeloid leukemia cells might relate to its proliferation and differentiation. PMID: 21548944
  11. ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56gamma3, B56gamma2 and B56delta, after DNA damage. PMID: 21460856
  12. the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A PMID: 20448040
  13. a mechanistic basis for the p53-dependent and -independent functions of B56gamma-PP2A PMID: 20473327
  14. B56gamma1 alters the dynamic assembly/disassembly process of nuclear speckles in heart cells. PMID: 15778281
  15. Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A PMID: 16524888
  16. B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. PMID: 17245430
  17. PP2A-B56gamma1 phosphatase complexes have a role in cardiac local signaling PMID: 17663574
  18. show an important link between ATM activity and the tumor-suppressive function of B56gamma-protein phosphatase 2A PMID: 17967874

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Subcellular Location Nucleus. Chromosome, centromere.
Protein Families Phosphatase 2A regulatory subunit B56 family
Tissue Specificity Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
Database Links

HGNC: 9311

OMIM: 601645

KEGG: hsa:5527

STRING: 9606.ENSP00000412324

UniGene: Hs.368264

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