PPP2R5C Antibody

1. PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma. PMID: 26986830
2. our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state. PMID: 26440364
3. propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF, AKT2, AKT3, NFKB2 and STAT3 genes PMID: 25888193
4. Differential expression of the transcripts PPP2R5C connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID: 25884766
5. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase. PMID: 25512391
6. Data indicate that the regulatory PP2A subunit B56gamma mediates suppression of NF-kappaB resulting in increased NF-kappaB target gene expression in T cells. PMID: 24719332
7. Results show that mutations lost B56gamma tumor-suppressive activity by two distinct mechanisms: one is by disrupting interactions with the PP2A AC core and the other with B56gamma-PP2A substrates (p53 and unknown proteins). PMID: 23723076
8. PPP2R5C-siRNA treatment altered gene expression profiles in malignant T cells PMID: 23941244
9. structural insight into the PP2A holoenzyme assembly and emphasizes the importance of HEAT repeat 1 in B56gamma-PP2A tumor-suppressive function PMID: 22315229
10. Overexpression of PPP2R5C in T-cell malignancy as well as in myeloid leukemia cells might relate to its proliferation and differentiation. PMID: 21548944
11. ataxia-telangiectasia mutated (ATM) directly phosphorylates and specifically regulates B56gamma3, B56gamma2 and B56delta, after DNA damage. PMID: 21460856
12. the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A PMID: 20448040
13. a mechanistic basis for the p53-dependent and -independent functions of B56gamma-PP2A PMID: 20473327
14. B56gamma1 alters the dynamic assembly/disassembly process of nuclear speckles in heart cells. PMID: 15778281
15. Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A PMID: 16524888
16. B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. PMID: 17245430
17. PP2A-B56gamma1 phosphatase complexes have a role in cardiac local signaling PMID: 17663574
18. show an important link between ATM activity and the tumor-suppressive function of B56gamma-protein phosphatase 2A PMID: 17967874

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HGNC: 9311

OMIM: 601645

KEGG: hsa:5527

STRING: 9606.ENSP00000412324

UniGene: Hs.368264