PPP4R2 Antibody

Code CSB-PA124096
Size US$297
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  • Western blot analysis of extracts from K562 cells and COS-7 cells, using PP4R2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PPP4R2 Polyclonal antibody
Uniprot No.
Target Names
PPP4R2
Alternative Names
BE691708 antibody; C230060M08Rik antibody; MGC131930 antibody; PP4R2 antibody; PP4R2_HUMAN antibody; PPP4R2 antibody; protein phosphatase 4, regulatory subunit 2 antibody; Serine/threonine protein phosphatase 4 regulatory subunit 2 antibody; Serine/threonine-protein phosphatase 4 regulatory subunit 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human PP4R2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Gene References into Functions
  1. Results from a study on gene expression variability markers in early-stage human embryos shows that PPP4R2 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
  2. Our results suggest that PATZ1 and PP4R2 provide negative feedback on IKK/NF-kappaB signaling to prevent cancer cells from over-stimulation from cellular stimuli PMID: 27391343
  3. PPP4R2 affects the survival of neuronal cells in response to DNA damage. PMID: 22559936
  4. PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit. PMID: 20154705
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Protein Families
PPP4R2 family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 18296

OMIM: 613822

KEGG: hsa:151987

STRING: 9606.ENSP00000349124

UniGene: Hs.431092

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