PRCP Antibody

Code CSB-PA241683
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA241683(PRCP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA241683(PRCP Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Jurkat cells, human fetal liver tissue, Primary antibody: CSB-PA241683(PRCP Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
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Product Details

Uniprot No. P42785
Target Names PRCP
Alternative Names Angiotensinase C antibody; HUMPCP antibody; Lysosomal carboxypeptidase C antibody; Lysosomal Pro X carboxypeptidase antibody; Lysosomal Pro-X carboxypeptidase antibody; MGC2202 antibody; PCP antibody; PCP_HUMAN antibody; PRCP antibody; Proline carboxypeptidase antibody; Prolylcarboxypeptidase (angiotensinase C) antibody; Prolylcarboxypeptidase antibody; prolylcarboxypeptidase isoform 1 preproprotein antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Fusion protein of Human PRCP
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:25-1:100
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Gene References into Functions
  1. For the first time, PRCP is identified as an apelin-cleaving enzyme. PMID: 27449720
  2. The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome PMID: 25370794
  3. PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation. PMID: 25324000
  4. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population. PMID: 22679278
  5. PRCP regulates cell growth, angiogenesis, and the response to vascular injury PMID: 23744584
  6. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors PMID: 22079761
  7. PRCP as a resistance factor for 4OHTAM resistance in estrogen receptor-positive breast cancer cells. PMID: 21087932
  8. A single peptide, with the sequence YPRPIHPA, as a novel substrate for PRCP in human cerebrospinal fluid. PMID: 20517885
  9. Purified PrCP yielded crystals belonging to space group R32, with unit-cell parameters a = b = 181.14, c = 240.13 A, that diffracted to better than 2.8 A resolution. PMID: 20516604
  10. A structure-based alignment with the previously undescribed structure of DPP7 illuminates the mechanism of orthogonal substrate specificity of PRCP and DPP7. PMID: 20540760
  11. Data suggest that the E112D polymorphism in the PRCP gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril treatment in hypertensive patients. PMID: 20079160
  12. PRCP appears to be a HUVEC-associated prekallikrein activator. PMID: 11830581
  13. Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator. PMID: 12123826
  14. recombinant protein, identical to enzyme from human umbilical vein endothelial cells, is a prekallikrein activator. PMID: 14996700
  15. Prolylcarboxypepdiase E112D (rs2298668)D allele alone and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia PMID: 16681991
  16. role in regulation cardiovascular tone; proinflammatory agent PMID: 18396440
  17. These investigations showed that the C-terminal region of the rPRCP(40) contributes to PRCP's catalytic function, and provided additional experimental evidence for this suggestion. PMID: 18656443

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Subcellular Location Lysosome
Protein Families Peptidase S28 family
Tissue Specificity Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
Database Links

HGNC: 9344

OMIM: 176785

KEGG: hsa:5547

STRING: 9606.ENSP00000377055

UniGene: Hs.523936

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