PRDM14 Antibody

1. Our results suggest that PRDM14 serves as an initial trigger for epigenetic changes and hyperdynamic plasticity in tumors via bivalent chromatin domains. PMID: 28423353
2. Results identified GRP78 and HSP90a as binding partners of PRDM14 in triple-negative breast cancer cells, and all participate in cancer regulation. The interactions were direct and required the C-terminal region including the zinc finger motifs of PRDM14. PMID: 29178343
3. miR-424-->cdc42-->prdm14 axis as a key molecular signalling cascade that might influence breast cancer progression in diabetic patients through hyperactivation of cancer stem cells. PMID: 29024936
4. High expression of PRDM14 is associated with liver metastasis in pancreatic cancer. PMID: 28498896
5. PRDM14 role in cell proliferation and cell migration PMID: 27693212
6. PRDM14 bears a single PR domain and six tandemly repeated zinc fi ngers, which is involved in the process of the deacetylation and methylation of the histone, and is involved in the formation of tumor . [review] PMID: 26903163
7. In response to cytokines, pluripotent stem cells differentiate first into a heterogeneous mesoderm-like cell population and then into Primordial Germ cell-Like Cells, which exhibit minimal PRDM14 expression. PMID: 25750208
8. The contribution of methylation-mediated gene silencing of PRDM14 to apoptosis evasion in HPV-positive cancer cells offers novel therapeutic options for HPV-induced cancers. PMID: 25233927
9. PRDM14 associated with cell differentiation in NSCLC. PMID: 23690269
10. Study reveals a repressive role of PRDM14 in the maintenance and induction of pluripotency and identifies PRDM14 as a new regulator of PRC2. PMID: 23280602
11. The high expression of PRDM14 in non-small cell lung cancer is associated with differentiation and histological type. PMID: 20840815
12. novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of hESC identity and the reacquisition of pluripotency in human somatic cells PMID: 20953172
13. PRDM14 mRNA is overexpressed in about two thirds of breast cancers; moreover, immunohistochemical analysis showed that expression of PRDM14 protein is also up-regulated. PMID: 17942894
14. These results suggest that PRDM14 is involved in the maintenance of the self-renewal of human ES cells by suppression of gene expression. PMID: 18194669

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HGNC: 14001

OMIM: 611781

KEGG: hsa:63978

STRING: 9606.ENSP00000276594

UniGene: Hs.736037