PREB Antibody, FITC conjugated

1. Administration of recombinant adenovirus containing human PREB to db/db, ob/ob, and DIO mice diminished glucose, insulin, and pyruvate tolerance indicating PREB to be a negative regulator of liver gluconeogenic genes. PMID: 29601978
2. Wls-SEC12 binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt secretion. These data suggest that formation of early Wnt secretory vesicles is carefully regulated to ensure proper export of functional ligands PMID: 28515233
3. These results indicate that PREB locates at the hepatitis C virus replication complex by interacting with NS4B. PMID: 26739056
4. Sec12, a guanine-nucleotide exchange factor for Sar1 guanosine triphosphatase, is concentrated at endoplasmic reticulum exit sites and that this concentration of Sec12 is specifically required for the secretion of collagen VII but not other proteins. PMID: 25202031
5. PREB regulates the cAMP-mediated transcription of the ABCA1 gene in vascular smooth muscle cells PMID: 20643408
6. The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells. PMID: 19426980

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HGNC: 9356

OMIM: 606395

KEGG: hsa:10113

STRING: 9606.ENSP00000260643

UniGene: Hs.279784