PRMT8 Antibody

Code CSB-PA018737GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PRMT8
Alternative Names
ANM8_HUMAN antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 4 antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 antibody; HMT1 hnRNP methyltransferase like 3 antibody; HMT1 hnRNP methyltransferase like 4 antibody; HRMT1 L3 antibody; HRMT1 L4 antibody; HRMT1L 3 antibody; HRMT1L 4 antibody; HRMT1L3 antibody; HRMT1L4 antibody; prmt8 antibody; Protein arginine N methyltransferase 4 antibody; Protein arginine N methyltransferase 8 antibody; Protein arginine N-methyltransferase 8 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PRMT8
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer. Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.
Gene References into Functions
  1. PRMT8 in human embryonic stem cells plays an important role not only in maintaining pluripotency but also in controlling mesodermal differentiation. PMID: 28543863
  2. Biochemical, biophysical and mutagenesis experiments demonstrated that hPRMT8 forms an octamer in solution. PMID: 26876602
  3. Mutational defects in PRMT8 is not the cause of frontotemporal lobar degeneration. PMID: 23635657
  4. automethylation of the N terminus likely regulates PRMT8 activity by decreasing the affinity of the enzyme for AdoMet PMID: 23946480
  5. wild type FUS (FUS-WT) specifically interacts with protein arginine methyltransferases 1 and 8 (PRMT1 and PRMT8) and undergoes asymmetric dimethylation PMID: 23620769
  6. PRMT8 is an active arginine methyltransferase that is membrane-associated and tissue-specific PMID: 16051612
  7. PRMT8 N-terminal domain may function as an autoregulator that may be displaced by interaction with one or more physiological inducers. PMID: 17925405
  8. The interaction between PRMT8 and the EWS protein was charcterized. PMID: 18320585
  9. EWS is a substrate for PRMT8, as efficient as for PRMT1 PMID: 18698489

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Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein Families
Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT8 subfamily
Tissue Specificity
Brain-specific.
Database Links

HGNC: 5188

OMIM: 610086

KEGG: hsa:56341

STRING: 9606.ENSP00000372067

UniGene: Hs.504530

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