PROKR1 Antibody

1. a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL)(P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population. PMID: 26984842
2. Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW] PMID: 26574895
3. EG-VEGF and its receptor PKR1 might play a role in the pathogenesis of adrenocortical tumors and could serve as prognostic markers for this rare malignant disease. PMID: 26475302
4. Expression of PROK1 and PROKR1 was significantly higher in mid-gestation ovaries (17-20 wk) than at earlier gestations (8-11 and 14-16 wk). PMID: 26192875
5. Study corroborates the clinical relevance of the EG-VEGF system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF and PROKR variants. PMID: 25064403
6. I397V variant confers lower risk for recurrent miscarriage PMID: 23687280
7. hCG increases EG-VEGF, PROKR1 and PROKR2 mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG in the regulation of EG-VEGF and its receptors PMID: 22138749
8. The results suggest an identical transmembrane-bundle binding site for hPKR1 and hPKR2. PMID: 22132188
9. Findings, together with the detection of sequence variants in PROKR1, PROK1 and PROKR2 genes associated to HSCR and, in some cases in combination with RET or GDNF mutations, provide evidence to consider them as susceptibility genes for HSCR. PMID: 21858136
10. The number of PKR1 is not reduced in preeclampsia. PMID: 21876489
11. Data suggest that smoking targets human Fallopian tubes via nAChRalpha-7 to increase tubal PROKR1, leading to alterations in the tubal microenvironment that could predispose to ectopic pregnancy. PMID: 20864676
12. Data show that expression of PK1 and PKR1 was detected in primary MM cells and myeloma cell lines. PMID: 20795791
13. Two tag SNPs of PKR1 (rs4627609, rs6731838) were significantly associated with idiopathic recurrent pregnancy loss. PMID: 20847187
14. Data shown that PROK1-PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua. PMID: 19801577
15. The functional characteristics of coronary endothelial cells depend on the expression of PKR1 and PKR2 levels and the divergent signaling pathways used by these receptors. PMID: 20023120
16. molecular cloning, amino acid sequence and expression in several human tissues PMID: 12427552
17. Paracrine role for the PKs and their receptors in endometrial vascular function. PMID: 15126578
18. study demonstrated that prokineticin 1 and 2 and their receptors are expressed in human prostate and that their levels increased with prostate malignancy PMID: 16763065
19. PROK1 and PROKR1 expression is elevated in human decidua during early pregnancy PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes. PMID: 18339712

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HGNC: 4524

OMIM: 607122

KEGG: hsa:10887

STRING: 9606.ENSP00000303775

UniGene: Hs.683430