PSD Antibody, FITC conjugated

Code CSB-PA018842LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PSD Polyclonal antibody
Uniprot No.
Target Names
PSD
Alternative Names
PSD antibody; EFA6 antibody; EFA6A antibody; KIAA2011 antibody; PSD1 antibody; TYL antibody; PH and SEC7 domain-containing protein 1 antibody; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 antibody; Exchange factor for ARF6 antibody; Exchange factor for ARF6 A antibody; Pleckstrin homology and SEC7 domain-containing protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human PH and SEC7 domain-containing protein 1 protein (247-489AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling.
Gene References into Functions
  1. Arf GTPases are likely to be locally activated by EFA6 and in turn targeted to the Flemming body to complete cytokinesis. PMID: 26330566
  2. PSD expression might be a useful biomarker for epigenetic-based gastric cancer early diagnosis and may lead to the identification of new targets for pharmacological intervention. PMID: 25355626
  3. EFA6 is regulated by a negative feedback loop, which is mediated by an allosteric interaction of Arf6-GTP with a domain of EFA6 and monitors the activation of Arf1 and Arf6 differentially PMID: 25114232
  4. EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis. PMID: 23603394
  5. Aberrant methylation of PSD occurs in UC-associated colorectal mucosa, enabling circumvention of Rac1 immune responses governing neutrophil chemotaxis and apoptosis, and plays a pivotal role in the mechanisms underlying UC-associated carcinogenesis. PMID: 22179719
  6. Both levels of accumulation of F-actin and apoptosis were significantly decreased in specimens from UC patients with PSD methylation compared to those without PSD methylation. PMID: 22002136
  7. Pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated advanced glycation end products (AGE) in diabetes. PMID: 17579087

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Subcellular Location
Cell membrane. Cell projection, ruffle membrane. Cleavage furrow.
Protein Families
PSD family
Tissue Specificity
Isoform 2 is expressed in the brain.
Database Links

HGNC: 9507

OMIM: 602327

KEGG: hsa:5662

STRING: 9606.ENSP00000020673

UniGene: Hs.154658

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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