PSMA7 Antibody

Datasheet

Code	CSB-PA01335A0Rb
Size	US$166
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Image	Western blot All lanes: PSMA7 antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 28, 21, 17 kDa Observed band size: 28 kDa Western blot All lanes: PSMA7 antibody at 1.6 µg/ml Lane 1: HepG2 whole cell lysate Lane 2: Mouse liver tissue Lane 3: Mouse kidney tissue Lane 4: Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 28, 21, 17 kDa Observed band size: 28 kDa Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA01335A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA01335A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA01335A0Rb at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA01335A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PSMA7 Polyclonal antibody

Uniprot No.

O14818

Target Names

PSMA7

Alternative Names

C6 antibody; HSPC antibody; MGC3755 antibody; OTTHUMP00000031449 antibody; OTTHUMP00000031450 antibody; OTTHUMP00000031453 antibody; Proteasome (prosome macropain) subunit alpha type 7 antibody; Proteasome alpha 7 subunit antibody; Proteasome subunit alpha 4 antibody; Proteasome subunit alpha type 7 antibody; Proteasome subunit alpha type-7 antibody; Proteasome subunit RC6 1 antibody; Proteasome subunit RC6-1 antibody; Proteasome subunit XAPC7 antibody; PSA7_HUMAN antibody; PSMA 7 antibody; PSMA7 antibody; RC6 1 antibody; XAPC7 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Proteasome subunit alpha type-7 protein (5-232AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PSMA7 Antibody (Product code: CSB-PA01335A0Rb) is Non-conjugated. For PSMA7 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA01335B0Rb	PSMA7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA01335C0Rb	PSMA7 Antibody, FITC conjugated
Biotin	CSB-PA01335D0Rb	PSMA7 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Gene References into Functions

salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with Inflammatory bowel disease. It can be a very promising biomarker PMID: 28523434
Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit 9 (PSMD9), proteasome alpha type 7 subunit (PSMA7) and PSMD13 genes. PMID: 26624926
c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit PMID: 25620702
PSMA7 functions partially through downregulation NOD1. PMID: 23839082
PSMA7 inhibits the proliferation, tumorigenicity and invasion of A549 cells in vitro PMID: 22584585
High expression of PSMA7 was significantly correlated with liver metastasis. PMID: 19062718
The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153. PMID: 16678104
PSMA7 may play an important role in colorectal cancer progression. PMID: 18202793
cell surface binding of EMAP-II results in its internalization into the cytoplasmic compartment where it interacts with PSMA7, a component of the proteasome degradation pathway. This interaction increases HIF-1alpha degradation under hypoxic conditions. PMID: 19362550

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Peptidase T1A family

Database Links

HGNC: 9536

OMIM: 606607

KEGG: hsa:5688

STRING: 9606.ENSP00000359910

UniGene: Hs.233952

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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