PSPC1 Antibody

Datasheet
Code CSB-PA018937LA01HU
See More Details
Size US$299
Uniprot No. Q8WXF1
Immunogen Recombinant Human Paraspeckle component 1 protein (191-299AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Paraspeckle component 1 (Paraspeckle protein 1), PSPC1, PSP1
Immunogen Species Human
Protocols ELISA Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names PSPC1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Subcellular Location Nucleus, nucleolus, Nucleus matrix, Cytoplasm, Nucleus speckle
Protein Families PSPC family
Tissue Specificity Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
Database Links

HGNC: 20320

OMIM: 612408

KEGG: hsa:55269

STRING: 9606.ENSP00000343966

UniGene: Hs.213198

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