PTGR2 Antibody

Datasheet

Code	CSB-PA018984LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate(30µg), MCF7 whole cell lysate(30µg), PC-3 whole cell lysate(30µg), A549 whole cell lysate(20µg), Mouse Heart tissue lysate(30µg) All lanes:PTGR2 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/20000 dilution Predicted band size: 39, 20 kDa Observed band size: 39 kDa Exposure time: 120s IHC image of CSB-PA018984LA01HU diluted at 1:165 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody IHC image of CSB-PA018984LA01HU diluted at 1:165 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PTGR2 Polyclonal antibody

Uniprot No.

Q8N8N7

Target Names

PTGR2

Alternative Names

15 oxoprostaglandin 13 reductase antibody; 15 oxoprostaglandin delta 13 reductase antibody; 15-oxoprostaglandin 13-reductase antibody; DKFZp686P10120 antibody; FLJ39091 antibody; FLJ99229 antibody; PGR 2 antibody; PGR2 antibody; PRG-2 antibody; Prostaglandin reductase 2 antibody; PTGR 2 antibody; PTGR2 antibody; PTGR2_HUMAN antibody; Zinc binding alcohol dehydrogenase domain containing 1 antibody; Zinc binding alcohol dehydrogenase domain containing protein 1 antibody; Zinc-binding alcohol dehydrogenase domain-containing protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Prostaglandin reductase 2 protein (206-282AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PTGR2 Antibody (Product code: CSB-PA018984LA01HU) is Non-conjugated. For PTGR2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018984LB01HU	PTGR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018984LC01HU	PTGR2 Antibody, FITC conjugated
Biotin	CSB-PA018984LD01HU	PTGR2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:3000
IHC	1:100-1:300

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

Gene References into Functions

Silencing of PTGR2 expression enhances reactive oxygen species production, suppresses pancreatic cell proliferation, and promotes cell death through increasing 15-keto-PGE2. PMID: 26820738
Functional data and clinical relevance for the role of PTGR2 in gastric cancer, are provided. PMID: 22998775
Cloning and tissue distribution of a splicing variant ZADH1b. PMID: 15004468
Besides targeting cyclooxygenase, indomethacin inhibits PTGR2 with a binding mode similar to that of 15-keto-PGE(2). PMID: 19000823

Subcellular Location

Cytoplasm.

Protein Families

NADP-dependent oxidoreductase L4BD family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 20149

OMIM: 608642

KEGG: hsa:145482

STRING: 9606.ENSP00000267568

UniGene: Hs.632344

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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