PTP4A2 Antibody

Datasheet

Code	CSB-PA613277LA01HU
Size	US$166
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Image	IHC image of CSB-PA613277LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA613277LA01HU diluted at 1:200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of Hela cells with CSB-PA613277LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PTP4A2 Polyclonal antibody

Uniprot No.

Q12974

Target Names

PTP4A2

Alternative Names

PTP4A2 antibody; PRL2 antibody; PTPCAAX2 antibody; BM-008 antibody; Protein tyrosine phosphatase type IVA 2 antibody; EC 3.1.3.48 antibody; HU-PP-1 antibody; OV-1 antibody; PTP(CAAXII) antibody; Protein-tyrosine phosphatase 4a2 antibody; Protein-tyrosine phosphatase of regenerating liver 2 antibody; PRL-2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein tyrosine phosphatase type IVA 2 protein (1-164AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PTP4A2 Antibody (Product code: CSB-PA613277LA01HU) is Non-conjugated. For PTP4A2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA613277LB01HU	PTP4A2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613277LC01HU	PTP4A2 Antibody, FITC conjugated
Biotin	CSB-PA613277LD01HU	PTP4A2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Gene References into Functions

identified a critical role for PRL2 phosphatase in the proliferation and survival of human AML cells. Further, we demonstrated that PRL2 is essential for the leukemogenic potential of AML1-ETO9a in vivo PMID: 28220038
Our findings highlight the important role of miR-29c in regulating CRC EMT via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A and provide new insights into the metastatic basis of colorectal cancer PMID: 25193986
PTP4A2 expression is correlated with overall survival in progestin receptor-positive breast carcinomas. PMID: 23568563
Results suggest a model in which PRL-2 promotes cell migration and invasion through an ERK1/2-dependent signaling pathway. PMID: 21765462
PRL-2 plays an important role in lung cancer and can be a biomarker of lung cancer, substituting for the function of other PRLs. PMID: 21993571
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. PMID: 20841483
Mouse pre-B-cells transfected with human PRL-2 had higher growth responses to Epo or IL-3, shorter cell cycle, less Epo requirement for survival, more cell migration, less cell adhesion, change to an immature cell morphology, & more Bmi-1 expression. PMID: 20226699
PRL-2 can promote cell adhesion and invasion activity of human hepatocellular carcinoma cells. PMID: 17666324
PRL-2 mRNA expression was not significantly higher in malignant compared to benign breast tissue. PMID: 16832410
PRL-2 was expressed heavily in almost every tissue and cell type examined. Widespread expression of PRL-2 in multiple organ systems suggests an important functional role for these enzymes in normal tissue homeostasis. PMID: 16957164

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Subcellular Location

Cell membrane. Early endosome. Cytoplasm.

Protein Families

Protein-tyrosine phosphatase family

Tissue Specificity

Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.

Database Links

HGNC: 9635

OMIM: 601584

KEGG: hsa:8073

STRING: 9606.ENSP00000344909

UniGene: Hs.470477

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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