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PYCR2 Antibody, HRP conjugated

Datasheet
Code CSB-PA822188LB01HU
Size US$166
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Product Details

Uniprot No.
Q96C36
Alternative Names
1810018M05Rik antibody; FLJ54750 antibody; Leftb antibody; OTTHUMP00000035614 antibody; P5C reductase 2 antibody; P5CR 2 antibody; P5CR2 antibody; P5CR2_HUMAN antibody; PYCR 2 antibody; PYCR2 antibody; Pyrroline 5 carboxylate reductase 2 antibody; Pyrroline 5 carboxylate reductase family member 2 antibody; Pyrroline 5 carboxylate reductase isoform antibody; Pyrroline-5-carboxylate reductase 2 antibody; RP4-559A3.4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pyrroline-5-carboxylate reductase 2 protein (2-320AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. Involved in cellular response to oxidative stress.
Gene References into Functions
  1. PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction. PMID: 27130255
  2. It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1. PMID: 26634742
  3. Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. PMID: 26733354
  4. Hypomyelination and the absence of lax caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable role for PYCR2 in the human CNS during development. PMID: 25865492
Involvement in disease
Leukodystrophy, hypomyelinating, 10 (HLD10)
Subcellular Location
Cytoplasm. Mitochondrion.
Protein Families
Pyrroline-5-carboxylate reductase family
Tissue Specificity
Detected in erythrocytes (at protein level). Expressed in fetal brain.
Database Links

HGNC: 30262

OMIM: 616406

KEGG: hsa:29920

STRING: 9606.ENSP00000342502

UniGene: Hs.654718

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