Pcsk2 Antibody, HRP conjugated

Code CSB-PA017642LB01RA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Pcsk2 Polyclonal antibody
Uniprot No.
Target Names
Pcsk2
Alternative Names
Pcsk2 antibody; Nec-2 antibody; Nec2 antibody; Rpc2 antibody; Neuroendocrine convertase 2 antibody; NEC 2 antibody; EC 3.4.21.94 antibody; KEX2-like endoprotease 2 antibody; Prohormone convertase 2 antibody; Proprotein convertase 2 antibody; PC2 antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat Neuroendocrine convertase 2 protein (109-637AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
Gene References into Functions
  1. The nutrient sensor sirtuin 1 regulates the production of CRH post-translationally by affecting PC2 post-translationally by affecting PC2. PMID: 26755731
  2. The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin. PMID: 19628676
  3. The prohormone convertase (PC) enzyme PC1 together with PC2 and PC5 may represent a redundant system to ensure production of biologically active cholecystokinin in rat brain PMID: 14608596
  4. Leptin regulates hypothalamic Pcsk2 expression and requires prohormone processing into mature peptides. PMID: 15286802
  5. study demonstrates abundant expression of PC2 mRNA in rat brain and shows that thyroid status regulated PC2 expression in the hypothalamus and cortex [PC2] PMID: 15585599
  6. Expression levels of POMC processing enzymes prohormone convertases 1 and 2 (PC1/PC2) were not significantly affected by high dietary salt intake in either WKY or SP-SHR tissues. PMID: 17531155
  7. our data anticipate the possibility that carboxypeptidase-E, prohormone convertase 1, and prohormone convertase 2 might be potential target for the maturation of somatostatin PMID: 17543468
  8. PC1/PC3 and PC2 (specific to neural and endocrine cells) are absent in undifferentiated bone marrow stromal stem cells, their expression is initiated upon the induction of differentiation PMID: 17556096
  9. brain ischemia attenuates PC2 and PC2-mediated neuropeptide processing. PMID: 19142196
  10. PC2, CPE and preproNPY protein expression levels were compared among mature retina tissue, RGC-5 cells and its differentiated cells; differentiated cells or tissues had higher or highest PC2 activity PMID: 19428990

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Subcellular Location
Cytoplasmic vesicle, secretory vesicle. Secreted.
Protein Families
Peptidase S8 family, Furin subfamily
Database Links
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