Pklr Antibody

Datasheet
Code CSB-PA018071LA01RA
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: Pklr antibody at 2µg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 63, 59 kDa
    Observed band size: 63 kDa
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) Pklr Polyclonal antibody
Uniprot No. P12928
Target Names Pklr
Alternative Names PklrPyruvate kinase PKLR antibody; EC 2.7.1.40 antibody; L-PK antibody; Pyruvate kinase isozymes L/R antibody
Raised in Rabbit
Species Reactivity Rat, Human
Immunogen Recombinant Rat Pyruvate kinase PKLR protein (1-574AA)
Immunogen Species Rattus norvegicus (Rat)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Plays a key role in glycolysis.
Gene References into Functions
  1. Studied the effect of the point mutations around this phosphorylation site on the catalytic properties of L-pyruvate kinase. PMID: 22878931
  2. c-Myc is required for the glucose-mediated induction of this metabolic enzyme. PMID: 12480946
  3. We observed that cystine inhibited the enzyme pyruvate kinase activity non-competitively in a dose- and time-dependent way. PMID: 15196592
  4. cooperative interaction between NF1 family members and HNF1alpha plays an important role in hepatic L-PK transcription PMID: 16204235
  5. Regulation of hepatic L-pyruvate kinase promoter composition and activity PMID: 16644726
  6. A novel chimeric promoter, consisting of a 1.6 kb glucose 6-phosphatase promoter and a segment of the regulatory element derived from the L-type pyruvate kinase promoter, was designed to provide strong and tight control of insulin expression in liver. PMID: 17160355
  7. Maximal glucose-induced expression of the L-PK gene in INS-1-derived 832/13 cells involves increased c-Myc abundance, recruitment of c-Myc, Max, and ChREBP to the promoter, and a glucose-stimulated increase in ChREBP transactivation. PMID: 17341548
  8. A detailed analysis of the molecular events of the insulin-independent glucose response of the liver-type pyruvate kinase (L-PK) gene was performed. PMID: 18468514
  9. cAMP and glucose signaling converge on a complex containing ChREBP, HNF4alpha, and CBP, and cAMP acts by disrupting this transcriptional complex assembled by glucose-derived signals PMID: 19406844
  10. Data show that glucose regulates acetylation and methylation of various histone residues at the L-PK gene promoter. PMID: 19631660

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Protein Families Pyruvate kinase family
Database Links

KEGG: rno:24651

STRING: 10116.ENSRNOP00000027700

UniGene: Rn.48821

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