RAB38 Antibody

Code CSB-PA008432
Size US$100
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Product Details

Uniprot No.
Target Names
RAB38
Alternative Names
Antigen NY MEL 1 antibody; Melanoma antigen NY MEL 1 antibody; Melanoma antigen NY-MEL-1 antibody; NY MEL 1 antibody; RAB 38 antibody; Rab related GTP binding protein antibody; Rab38 antibody; RAB38 member RAS oncogene family antibody; RAB38_HUMAN antibody; Ras related protein Rab 38 antibody; Ras-related protein Rab-38 antibody; rrGTPbp antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Rab 38.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
Gene References into Functions
  1. Rab38 was associated with albuminuria in type 2 diabetes patients. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared with control subjects. PMID: 26631737
  2. MiR-124 significantly decreases the H2O2-induced apoptosis of human hepatic L02 cells by targeting the Rab38 gene and activating the AKT pathway. PMID: 24875359
  3. The expression levels of RAB38 were significantly associated with grade progression as well as prognosis in gliomas. RAB38 is an important prognostic biomarker and potential therapeutic target in gliomas. PMID: 24026199
  4. Studies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML. PMID: 20103624
  5. Not a new major locus for Japanese oculocutaneous albinisms. PMID: 12850305
  6. Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo. PMID: 18477474

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Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome membrane.
Protein Families
Small GTPase superfamily, Rab family
Tissue Specificity
Expressed in melanocytes.
Database Links

HGNC: 9776

OMIM: 606281

KEGG: hsa:23682

STRING: 9606.ENSP00000243662

UniGene: Hs.591975

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