RAB38 Antibody, FITC conjugated

Datasheet

Code	CSB-PA019191LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAB38 Polyclonal antibody

Uniprot No.

P57729

Target Names

RAB38

Alternative Names

Antigen NY MEL 1 antibody; Melanoma antigen NY MEL 1 antibody; Melanoma antigen NY-MEL-1 antibody; NY MEL 1 antibody; RAB 38 antibody; Rab related GTP binding protein antibody; Rab38 antibody; RAB38 member RAS oncogene family antibody; RAB38_HUMAN antibody; Ras related protein Rab 38 antibody; Ras-related protein Rab-38 antibody; rrGTPbp antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ras-related protein Rab-38 protein (1-211AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.

Gene References into Functions

Rab38 was associated with albuminuria in type 2 diabetes patients. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared with control subjects. PMID: 26631737
MiR-124 significantly decreases the H2O2-induced apoptosis of human hepatic L02 cells by targeting the Rab38 gene and activating the AKT pathway. PMID: 24875359
The expression levels of RAB38 were significantly associated with grade progression as well as prognosis in gliomas. RAB38 is an important prognostic biomarker and potential therapeutic target in gliomas. PMID: 24026199
Studies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML. PMID: 20103624
Not a new major locus for Japanese oculocutaneous albinisms. PMID: 12850305
Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo. PMID: 18477474

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome membrane.

Protein Families

Small GTPase superfamily, Rab family

Tissue Specificity

Expressed in melanocytes.

Database Links

HGNC: 9776

OMIM: 606281

KEGG: hsa:23682

STRING: 9606.ENSP00000243662

UniGene: Hs.591975

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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