RALB Antibody

Code CSB-PA019297ESR2HU
Size US$166
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  • Western blot
    All lanes: RALB antibody at 1.26µg/ml
    Lane 1: Mouse brain tissue
    Lane 2: Mouse lung tissue
    Lane 3: MCF-7 whole cell lysate
    Lane 4: HepG2 whole cell lysate
    Lane 5: Jurkat whole cell lysate
    Lane 6: NIH/3T3 whole cell lysate
    Lane 7: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 24, 26 kDa
    Observed band size: 26 kDa

  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA019297ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RALB Polyclonal antibody
Uniprot No.
Target Names
RALB
Alternative Names
5730472O18Rik antibody; dRalb antibody; GTP binding protein antibody; Ralb antibody; RALB_HUMAN antibody; RAS like protein B antibody; RAS like proto oncogene B antibody; Ras related GTP binding protein B antibody; Ras-related protein Ral-B antibody; v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody; v ral simian leukemia viral oncogene homolog B (ras related) antibody; V ral simian leukemia viral oncogene homolog B antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Ras-related protein Ral-B protein (1-206AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors.
Gene References into Functions
  1. our work provides new insight into the specific roles of Ras effector pathways in acute myeloid leukemia and has identified RALB signaling as a key survival pathway PMID: 27556501
  2. High RALB expression is associated with acute myeloid leukemia. PMID: 27991934
  3. Inhibition of Ral GTPases Using a Stapled Peptide Approach. PMID: 27334922
  4. These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I. PMID: 25573158
  5. High RALB mRNA expression is associated with non-small-cell lung cancer growth and progression. PMID: 24389431
  6. Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance. PMID: 24747441
  7. nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles PMID: 24056301
  8. a novel RalB-mediated biochemical and signaling mechanism for invadopodium formation PMID: 22331470
  9. Study finds that the Ras-like small G protein, RalB, is localized to nascent autophagosomes and is activated on nutrient deprivation. PMID: 21241894
  10. Non-phosphorylated RalB is associated with bladder cancer cell growth and metastasis. PMID: 20940393
  11. RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival; RALB is specifically required for survival of tumour cells but not normal cells PMID: 12856001
  12. These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
  13. RalB was found to mediate SDF-1-induced migration PMID: 18227351
  14. Backbone dynamics and the structure of free RalB bound to the GTP analogue GMPPNP were determined using NMR spectroscopy. PMID: 19166349
  15. 1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation. Backbone amide dynamics parameters for a majority of residues have also been obtained PMID: 19636851

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Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody.
Protein Families
Small GTPase superfamily, Ras family
Database Links

HGNC: 9840

OMIM: 179551

KEGG: hsa:5899

STRING: 9606.ENSP00000272519

UniGene: Hs.469820

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