RALB Antibody

Datasheet

Code	CSB-PA019297ESR2HU
Size	US$166
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Image	Western blot All lanes: RALB antibody at 1.26µg/ml Lane 1: Mouse brain tissue Lane 2: Mouse lung tissue Lane 3: MCF-7 whole cell lysate Lane 4: HepG2 whole cell lysate Lane 5: Jurkat whole cell lysate Lane 6: NIH/3T3 whole cell lysate Lane 7: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 24, 26 kDa Observed band size: 26 kDa Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA019297ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RALB Polyclonal antibody

Uniprot No.

P11234

Target Names

RALB

Alternative Names

5730472O18Rik antibody; dRalb antibody; GTP binding protein antibody; Ralb antibody; RALB_HUMAN antibody; RAS like protein B antibody; RAS like proto oncogene B antibody; Ras related GTP binding protein B antibody; Ras-related protein Ral-B antibody; v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody; v ral simian leukemia viral oncogene homolog B (ras related) antibody; V ral simian leukemia viral oncogene homolog B antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Ras-related protein Ral-B protein (1-206AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors.

Gene References into Functions

our work provides new insight into the specific roles of Ras effector pathways in acute myeloid leukemia and has identified RALB signaling as a key survival pathway PMID: 27556501
High RALB expression is associated with acute myeloid leukemia. PMID: 27991934
Inhibition of Ral GTPases Using a Stapled Peptide Approach. PMID: 27334922
These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I. PMID: 25573158
High RALB mRNA expression is associated with non-small-cell lung cancer growth and progression. PMID: 24389431
Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance. PMID: 24747441
nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles PMID: 24056301
a novel RalB-mediated biochemical and signaling mechanism for invadopodium formation PMID: 22331470
Study finds that the Ras-like small G protein, RalB, is localized to nascent autophagosomes and is activated on nutrient deprivation. PMID: 21241894
Non-phosphorylated RalB is associated with bladder cancer cell growth and metastasis. PMID: 20940393
RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival; RALB is specifically required for survival of tumour cells but not normal cells PMID: 12856001
These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
RalB was found to mediate SDF-1-induced migration PMID: 18227351
Backbone dynamics and the structure of free RalB bound to the GTP analogue GMPPNP were determined using NMR spectroscopy. PMID: 19166349
1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation. Backbone amide dynamics parameters for a majority of residues have also been obtained PMID: 19636851

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody.

Protein Families

Small GTPase superfamily, Ras family

Database Links

HGNC: 9840

OMIM: 179551

KEGG: hsa:5899

STRING: 9606.ENSP00000272519

UniGene: Hs.469820

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ras signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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