RANBP3 Antibody

Datasheet

Code	CSB-PA867162DSR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA867162DSR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA867162DSR1HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RANBP3 Polyclonal antibody

Uniprot No.

Q9H6Z4

Target Names

RANBP3

Alternative Names

DKFZp586I1520 antibody; Ran binding protein 3 antibody; Ran-binding protein 3 antibody; RANB3_HUMAN antibody; RanBP3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ran-binding protein 3 protein (1-250AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Gene References into Functions

Computational docking simulation indicates that phosphorylation of RanBP3 at Ser58 could potentially stabilize the association of RanBP3 with importin-alpha through interactions between the phosphate moiety of phospho-Ser58 of RanBP3 and a cluster of basic residues (Arg96 and Lys97 in importin-alpha3) on armadillo repeat 1 of importin-alpha. PMID: 28760339
RANBP3 regulates melanoma cell proliferation and probably a potential target for molecular targeted therapy. PMID: 26763446
RanBP3 is involved in vRNP nuclear export. The function of RanBP3 during vRNP nuclear export is regulated by phosphorylation at Ser58. RanBP3 phosphorylation is modulated by both PI3K/Akt and Ras/ERK/RSK pathways in the late phase of viral infection. PMID: 23303829
Crystal structure of the Ran-binding domain (RBD) from RanBP3 and compare it to RBD structures from RanBP1 and RanBP2 in complex with Ran and CRM1. PMID: 21364925
RanBP3 stimulates export by enhancing the affinity of Crm1 for Ran-GTP and cargo. PMID: 11932251
A multifunctional domain in CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. PMID: 14612415
RANBP3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. PMID: 18280241
RanBP3 directly recognizes dephosphorylated Smad2/3, which results from the activity of nuclear Smad phosphatases, and mediates nuclear export of Smad2/3 in a Ran-dependent manner. PMID: 19289081

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Widely expressed with high levels in testis and heart.

Database Links

HGNC: 9850

OMIM: 603327

KEGG: hsa:8498

STRING: 9606.ENSP00000341483

UniGene: Hs.531752

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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