RASA3 Antibody

Code CSB-PA019348GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RASA3
Alternative Names
GAP III antibody; GAP1(IP4BP) antibody; GAP1IP4BP antibody; GAPIII antibody; GTPase activating protein 1 family antibody; GTPase activating protein III antibody; Inositol 1 3 4 5 tetrakisphosphate binding protein antibody; Inositol 1345 tetrakisphosphate binding protein antibody; Ins P4 binding protein antibody; Ins P4-binding protein antibody; Ins(1 3 4 5)P4 binding protein antibody; Ins(1345)P4 binding protein antibody; MGC46517 antibody; MGC47588 antibody; Ras GTPase activating protein 3 antibody; Ras GTPase-activating protein 3 antibody; RAS p21 protein activator 3 antibody; RASA 3 antibody; RASA3 antibody; RASA3_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RASA3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.
Gene References into Functions
  1. Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype. PMID: 29381707
  2. these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. PMID: 27903653
  3. the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. PMID: 25294679
  4. role in intracellular calcium homeostasis PMID: 12356770
  5. model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger PMID: 19433443
  6. GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate. PMID: 7637787

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Subcellular Location
Cell membrane.
Database Links

HGNC: 20331

OMIM: 605182

KEGG: hsa:22821

STRING: 9606.ENSP00000335029

UniGene: Hs.593075

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