RASA3 Antibody

Datasheet

Code	CSB-PA002639
Size	US$119
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Image	Western Blot analysis of HeLa cells using GAP1-InsP4 BP Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q14644

Target Names

RASA3

Alternative Names

GAP III antibody; GAP1(IP4BP) antibody; GAP1IP4BP antibody; GAPIII antibody; GTPase activating protein 1 family antibody; GTPase activating protein III antibody; Inositol 1 3 4 5 tetrakisphosphate binding protein antibody; Inositol 1345 tetrakisphosphate binding protein antibody; Ins P4 binding protein antibody; Ins P4-binding protein antibody; Ins(1 3 4 5)P4 binding protein antibody; Ins(1345)P4 binding protein antibody; MGC46517 antibody; MGC47588 antibody; Ras GTPase activating protein 3 antibody; Ras GTPase-activating protein 3 antibody; RAS p21 protein activator 3 antibody; RASA 3 antibody; RASA3 antibody; RASA3_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human GAP1-InsP4 BP.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.

Gene References into Functions

Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype. PMID: 29381707
these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. PMID: 27903653
the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. PMID: 25294679
role in intracellular calcium homeostasis PMID: 12356770
model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger PMID: 19433443
GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate. PMID: 7637787

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Subcellular Location

Cell membrane.

Database Links

HGNC: 20331

OMIM: 605182

KEGG: hsa:22821

STRING: 9606.ENSP00000335029

UniGene: Hs.593075

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ras signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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