RASAL2 Antibody

Code CSB-PA890908LA01HU
Size US$166
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Image
  • IHC image of CSB-PA890908LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA890908LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RASAL2 Polyclonal antibody
Uniprot No.
Target Names
RASAL2
Alternative Names
nGAP antibody; NGAP_HUMAN antibody; Ras GTPase-activating protein nGAP antibody; Ras protein activator like 1 antibody; RAS protein activator-like 2 antibody; RASAL2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ras GTPase-activating protein nGAP protein (749-835AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RASAL2 Antibody (Product code: CSB-PA890908LA01HU) is Non-conjugated. For RASAL2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA890908LB01HU RASAL2 Antibody, HRP conjugated ELISA
FITC CSB-PA890908LC01HU RASAL2 Antibody, FITC conjugated
Biotin CSB-PA890908LD01HU RASAL2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibitory regulator of the Ras-cyclic AMP pathway.
Gene References into Functions
  1. Furthermore, overexpression of miR-203 exhibited a similar effect to RASAL2 knockdown in hepatocellular carcinoma (HCC) cells. These results indicated that RASAL2 serves a tumor oncogenic role in HCC and may be considered a potential target in HCC. PMID: 28447723
  2. Study shows that up to 62% of luminal B cancers have lost expression of at least one of the DAB2IP and RASAL2 genes. However, the tumors that have lost both genes frequently present as advanced disease and are more likely to recur. Importantly, the report provide evidence that DAB2IP and RASAL2 can individually function as tumor suppressors in breast cancer. PMID: 27974415
  3. RASAL2 could inhibit BCa tumorigenesis. PMID: 28182001
  4. these results demonstrated that miRNA-136 was a key anti-invasive miRNA and further confirmed the oncogenic role of RASAL2 in triple-negative breast cancer. PMID: 27108696
  5. High RASAL2 expression is associated with liver cancer. PMID: 24763612
  6. these results indicate that activation of a RASAL2/ARHGAP24/RAC1 module contributes to TNBC tumorigenesis and identify a context-dependent role of RASAL2 in breast cancer. PMID: 25384218
  7. Results implicate RASAL2 as an EMT regulator and tumor suppressor in ovarian cancer, and down-regulation of RASAL2 promotes ovarian cancer progression. PMID: 25216515
  8. the down-regulation of RASAL2 promotes metastatic progression of lung adenocarcinoma PMID: 25446096
  9. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. PMID: 24029233
  10. RASAL2 was identified as an ECT2-interacting protein that regulates RHO activity in astrocytoma cells. PMID: 22683310

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Database Links

HGNC: 9874

OMIM: 606136

KEGG: hsa:9462

STRING: 9606.ENSP00000356621

UniGene: Hs.496139

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