RASAL2 Antibody

Datasheet

Code	CSB-PA890908LA01HU
Size	US$166
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Image	IHC image of CSB-PA890908LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of Hela cells with CSB-PA890908LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RASAL2 Polyclonal antibody

Uniprot No.

Q9UJF2

Target Names

RASAL2

Alternative Names

nGAP antibody; NGAP_HUMAN antibody; Ras GTPase-activating protein nGAP antibody; Ras protein activator like 1 antibody; RAS protein activator-like 2 antibody; RASAL2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ras GTPase-activating protein nGAP protein (749-835AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RASAL2 Antibody (Product code: CSB-PA890908LA01HU) is Non-conjugated. For RASAL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA890908LB01HU	RASAL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA890908LC01HU	RASAL2 Antibody, FITC conjugated
Biotin	CSB-PA890908LD01HU	RASAL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Inhibitory regulator of the Ras-cyclic AMP pathway.

Gene References into Functions

Furthermore, overexpression of miR-203 exhibited a similar effect to RASAL2 knockdown in hepatocellular carcinoma (HCC) cells. These results indicated that RASAL2 serves a tumor oncogenic role in HCC and may be considered a potential target in HCC. PMID: 28447723
Study shows that up to 62% of luminal B cancers have lost expression of at least one of the DAB2IP and RASAL2 genes. However, the tumors that have lost both genes frequently present as advanced disease and are more likely to recur. Importantly, the report provide evidence that DAB2IP and RASAL2 can individually function as tumor suppressors in breast cancer. PMID: 27974415
RASAL2 could inhibit BCa tumorigenesis. PMID: 28182001
these results demonstrated that miRNA-136 was a key anti-invasive miRNA and further confirmed the oncogenic role of RASAL2 in triple-negative breast cancer. PMID: 27108696
High RASAL2 expression is associated with liver cancer. PMID: 24763612
these results indicate that activation of a RASAL2/ARHGAP24/RAC1 module contributes to TNBC tumorigenesis and identify a context-dependent role of RASAL2 in breast cancer. PMID: 25384218
Results implicate RASAL2 as an EMT regulator and tumor suppressor in ovarian cancer, and down-regulation of RASAL2 promotes ovarian cancer progression. PMID: 25216515
the down-regulation of RASAL2 promotes metastatic progression of lung adenocarcinoma PMID: 25446096
The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. PMID: 24029233
RASAL2 was identified as an ECT2-interacting protein that regulates RHO activity in astrocytoma cells. PMID: 22683310

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Database Links

HGNC: 9874

OMIM: 606136

KEGG: hsa:9462

STRING: 9606.ENSP00000356621

UniGene: Hs.496139

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ras signaling pathway Melanogenesis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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