RASD2 Antibody

Code CSB-PA008395
Size US$100
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Product Details

Uniprot No.
Target Names
RASD2
Alternative Names
GTP binding protein Rhes antibody; GTP-binding protein Rhes antibody; MGC:4834 antibody; OTTHUMP00000197925 antibody; Ras homolog enriched in striatum antibody; RASD 2 antibody; RASD family member 2 antibody; RASD2 antibody; Rhes antibody; RHES_HUMAN antibody; TEM 2 antibody; TEM2 antibody; Tumor endothelial marker 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human Dexras2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Gene References into Functions
  1. Study demonstrated that variation in the gene coding for RASD2 (rs6518956) affects in vivo prefrontal and striatal phenotypes in healthy human subjects that are relevant to schizophrenia PMID: 26228524
  2. Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion PMID: 26190541
  3. Findings reveal that ras homolog enriched in striatum is localized also in striatal cholinergic interneurons and, most importantly, lack of this G-protein, significantly alters dopamine D2 receptor modulation of striatal cholinergic excitability. PMID: 25818655
  4. Rhes is reduced in the brains of Huntington's disease patients. PMID: 25556834
  5. The findings of this study suggested that Rhes may play a crucial role in striatal iron homeostasis. PMID: 23999124
  6. Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling. PMID: 24324270
  7. The sequestering of Rhes through its binding to mutant huntingtin may decrease the ability of Rhes to perform vital physiological functions in the striatum neurons of Huntington disease patients. (Review) PMID: 23583659
  8. Rhes is an imidazoline-regulated transcript in pancreatic beta-cells PMID: 16945334
  9. Rhes can interfere with the functional activity of wt and mutated TSHr and with the respective hormone-stimulated cAMP production of FSHr and LHr. PMID: 17556863
  10. The genes RASD2 might be vulnerability genes for neuropsychologically defined subgroups of schizophrenic patients. PMID: 18571626
  11. Binding to the Gbeta subunits involves the cationic regions of AGS1 and Rhes, and Data used Rhes-AGS1 chimeras to show that their different cationic regions determine the Gbeta-specificity of the interactions. PMID: 19255495

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Subcellular Location
Cell membrane; Lipid-anchor.
Protein Families
Small GTPase superfamily, RasD family
Tissue Specificity
Pancreatic endocrine cells (islets of Langerhans).
Database Links

HGNC: 18229

OMIM: 612842

KEGG: hsa:23551

STRING: 9606.ENSP00000216127

UniGene: Hs.474711

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