RASD2 Antibody

Code CSB-PA249540
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA249540(RASD2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA249540(RASD2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cell and mouse kidney tissue, Primary antibody: CSB-PA249540(RASD2 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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Product Details

Uniprot No. Q96D21
Target Names RASD2
Alternative Names GTP binding protein Rhes antibody; GTP-binding protein Rhes antibody; MGC:4834 antibody; OTTHUMP00000197925 antibody; Ras homolog enriched in striatum antibody; RASD 2 antibody; RASD family member 2 antibody; RASD2 antibody; Rhes antibody; RHES_HUMAN antibody; TEM 2 antibody; TEM2 antibody; Tumor endothelial marker 2 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Full length fusion protein
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:25-1:100
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : the correlation analysis

Sample type: cells

Review: the correlation analysis of screened hub genes and LVEF. The expression levels of RASD2, SLIT2, and IQGAP2 were not correlated with cardiac function.

By Anonymous

Target Background

Function
(From Uniprot)
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Gene References into Functions
  1. Study demonstrated that variation in the gene coding for RASD2 (rs6518956) affects in vivo prefrontal and striatal phenotypes in healthy human subjects that are relevant to schizophrenia PMID: 26228524
  2. Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion PMID: 26190541
  3. Findings reveal that ras homolog enriched in striatum is localized also in striatal cholinergic interneurons and, most importantly, lack of this G-protein, significantly alters dopamine D2 receptor modulation of striatal cholinergic excitability. PMID: 25818655
  4. Rhes is reduced in the brains of Huntington's disease patients. PMID: 25556834
  5. The findings of this study suggested that Rhes may play a crucial role in striatal iron homeostasis. PMID: 23999124
  6. Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling. PMID: 24324270
  7. The sequestering of Rhes through its binding to mutant huntingtin may decrease the ability of Rhes to perform vital physiological functions in the striatum neurons of Huntington disease patients. (Review) PMID: 23583659
  8. Rhes is an imidazoline-regulated transcript in pancreatic beta-cells PMID: 16945334
  9. Rhes can interfere with the functional activity of wt and mutated TSHr and with the respective hormone-stimulated cAMP production of FSHr and LHr. PMID: 17556863
  10. The genes RASD2 might be vulnerability genes for neuropsychologically defined subgroups of schizophrenic patients. PMID: 18571626
  11. Binding to the Gbeta subunits involves the cationic regions of AGS1 and Rhes, and Data used Rhes-AGS1 chimeras to show that their different cationic regions determine the Gbeta-specificity of the interactions. PMID: 19255495

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Subcellular Location Cell membrane; Lipid-anchor.
Protein Families Small GTPase superfamily, RasD family
Tissue Specificity Pancreatic endocrine cells (islets of Langerhans).
Database Links

HGNC: 18229

OMIM: 612842

KEGG: hsa:23551

STRING: 9606.ENSP00000216127

UniGene: Hs.474711

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