Product Details

Uniprot No.

Target Names

RBM39

Alternative Names

CAPER alpha antibody; CAPER antibody; CAPERalpha antibody; CC1.3 antibody; Coactivator of activating protein 1 and estrogen receptors antibody; Coactivator of AP1 and ERs antibody; DKFZp781C0423 antibody; FLJ44170 antibody; HCC 1 antibody; Hepatocellular carcinoma protein 1 antibody; RBM 39 antibody; RBM39 antibody; RBM39_HUMAN antibody; RNA binding motif protein 39 antibody; RNA binding region (RNP1 RRM) containing 2 antibody; RNA binding region containing 2 antibody; RNA binding region containing protein 2 antibody; RNA-binding motif protein 39 antibody; RNA-binding protein 39 antibody; RNA-binding region-containing protein 2 antibody; RNPC 2 antibody; RNPC2 antibody; Splicing factor CC1.3 antibody; Splicing factor CC1.4 antibody; Splicing factor HCC 1 antibody; Splicing factor HCC1 antibody; Transcription coactivator CAPER antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human RBM39

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.

Gene References into Functions

Decreased expression of CAPERalpha appears to be correlated with appearance of microvessels in hepatocellular carcinoma PMID: 26934653
RBM39 is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 may modulate alternative splicing similarly to U2AF65 by either directly binding to RNA or recruiting other splicing factors, such as U2AF65. PMID: 27354116
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1, and RBM39 stabilizes or increases U2 snRNP recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation. PMID: 28193846
This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35, U2AF65, RBM39 and SF3b155, and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells. PMID: 27050129
mammalian c-Abl plays an important role in steroid hormone receptor-mediated transcription by regulating RBM39 PMID: 27018250
Knockdown of CAPER expression markedly reduced human breast cancer cell proliferation in both in vitro and in vivo settings. Mechanistically, knockdown of CAPER abrogated the activity of proliferative and protein synthesis pathways. PMID: 24621503
Our data suggest that overexpression of HCC1/CAPERalpha may increase the proliferation and migration of NSCLC cells, and HCC1/CAPERalpha could be a promising biomarker for lung cancer PMID: 24643682
identify SF3b155 as the relevant ULM-containing partner of full-length CAPERalpha in human cell extracts. PMID: 24795046
Data show that CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. PMID: 22711543
Increased VEGF(165) expression is secondary to the down-regulation of CAPER-alpha by EWS/FLI-1. CAPER-alpha mediates alternative splicing and controls the shift from VEGF(189) to VEGF(165) . PMID: 22009261
10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h PMID: 15747776
this study identifies CAPERalpha (RNA binding motif protein 39) as a new transcriptional coregulator for v-Rel and reveals an important role in modulating Rel's oncogenic activity. PMID: 18753212
Analysis of human breast cancer samples revealed that CAPER is overexpressed and undergoes a cytoplasmic-to-nuclear shift during the transition from pre-malignancy to ductal carcinoma in situ PMID: 19342371
This paper describes the mouse gene. PMID: 11704680