RBM39

RBM39 (RNA Binding Motif Protein 39), also known as HCC1 or CAPERα, is a splicing factor critical for spliceosome assembly and mRNA processing. It regulates alternative splicing by binding to pre-mRNA through its RNA recognition motif (RRM) and participates in transcriptional coactivation with nuclear receptors like ERα and SRC-1. RBM39 modulates key pathways including Wnt/β-catenin, TGF-β, and Notch signaling, impacting cell cycle progression and differentiation. Dysregulation of RBM39 is implicated in hematologic malignancies (e.g., acute myeloid leukemia), solid tumors, and autoimmune disorders due to aberrant splicing of oncogenes or tumor suppressors. Pharmacologically, RBM39 has emerged as a target for molecular glue degraders. Indisulam, a sulfonamide compound, selectively induces RBM39 proteasomal degradation by recruiting DCAF15 E3 ligase, showing clinical efficacy in phase II trials for relapsed lymphomas and sarcomas. Resistance mechanisms and combination therapies with PARP inhibitors are under active investigation.

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Recombinant Human RNA-binding protein 39 (RBM39)