RFC2 Antibody

Code CSB-PA040210
Size US$100
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Product Details

Uniprot No.
Target Names
RFC2
Alternative Names
A1 40 kDa subunit antibody; A1 antibody; Activator 1 40 kDa subunit antibody; Activator 1 antibody; Activator 1 subunit 2 antibody; MGC3665 antibody; OTTHUMP00000160645 antibody; OTTHUMP00000160646 antibody; Replication factor C (activator 1) 2 40kDa antibody; Replication factor C (activator 1) 2 antibody; Replication factor C 2 antibody; Replication factor C 40 kDa subunit antibody; Replication factor C subunit 2 antibody; RF C 40 kDa subunit antibody; RF-C 40 kDa subunit antibody; RFC 2 antibody; RFC 40 antibody; RFC 40 kDa subunit antibody; RFC2 antibody; RFC2_HUMAN antibody; RFC40 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human RFC2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP.
Gene References into Functions
  1. Upregulation by BCR/ABL requires activation of STAT5 and plays a key role in the BCR/ABL-mediated cell protection from apoptosis. PMID: 12036885
  2. The cAMP functions as an upstream modulator that regulates the expression and nuclear translocation of RFC40 protein. PMID: 16413017
  3. RPA plays a regulatory role in DNA damage responses via repression of RFC2 ubiquitylation in human cells. PMID: 18245774
Involvement in disease
RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).
Subcellular Location
Nucleus.
Protein Families
Activator 1 small subunits family
Database Links

HGNC: 9970

OMIM: 194050

KEGG: hsa:5982

STRING: 9606.ENSP00000055077

UniGene: Hs.647062

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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