RFC2 Antibody

Datasheet

Code	CSB-PA040210
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P35250

Target Names

RFC2

Alternative Names

A1 40 kDa subunit antibody; A1 antibody; Activator 1 40 kDa subunit antibody; Activator 1 antibody; Activator 1 subunit 2 antibody; MGC3665 antibody; OTTHUMP00000160645 antibody; OTTHUMP00000160646 antibody; Replication factor C (activator 1) 2 40kDa antibody; Replication factor C (activator 1) 2 antibody; Replication factor C 2 antibody; Replication factor C 40 kDa subunit antibody; Replication factor C subunit 2 antibody; RF C 40 kDa subunit antibody; RF-C 40 kDa subunit antibody; RFC 2 antibody; RFC 40 antibody; RFC 40 kDa subunit antibody; RFC2 antibody; RFC2_HUMAN antibody; RFC40 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human RFC2.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP.

Gene References into Functions

Upregulation by BCR/ABL requires activation of STAT5 and plays a key role in the BCR/ABL-mediated cell protection from apoptosis. PMID: 12036885
The cAMP functions as an upstream modulator that regulates the expression and nuclear translocation of RFC40 protein. PMID: 16413017
RPA plays a regulatory role in DNA damage responses via repression of RFC2 ubiquitylation in human cells. PMID: 18245774

Involvement in disease

RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).

Subcellular Location

Nucleus.

Protein Families

Activator 1 small subunits family

Database Links

HGNC: 9970

OMIM: 194050

KEGG: hsa:5982

STRING: 9606.ENSP00000055077

UniGene: Hs.647062

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

DNA repair pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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