RFC3 Antibody

Datasheet

Code	CSB-PA019590GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P40938

Target Names

RFC3

Alternative Names

A1 38 kDa subunit antibody; Activator 1 38 kDa subunit antibody; Activator 1 subunit 3 antibody; HGNC:9971 antibody; MGC5276 antibody; Replication factor C (activator 1) 3 antibody; Replication factor C (activator 1) 3, 38kDa antibody; Replication factor C 3 antibody; Replication factor C 38 kDa subunit antibody; Replication factor C subunit 3 antibody; RF-C 38 kDa subunit antibody; RFC 38 kD subunit antibody; RFC 38 kDa subunit antibody; RFC3 antibody; RFC3_HUMAN antibody; RFC38 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human RFC3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Gene References into Functions

The expression level of RFC3 was markedly upregulated in the HCC tissues and cells. PMID: 26397132
The expression level of RFC3 was remarkably up-regulated in ovarian cancer OVCAR-3 cells. Down-regulation of RFC3 expression arrested the cell cycle of OVCAR-3 cell in the S-phase and induced apoptosis. PMID: 26464638
High RFC3 expression is associated with neoplastic myelopoiesis. PMID: 25541153
our findings suggest that RFC3 protein is an important and independent biomarker with prognostic implications for patients with ovarian carcinoma. PMID: 25030735
9-cis-RA-activated RXRalpha suppresses the growth of retinoid-sensitive breast cancer and embryonic cells through RFC3. PMID: 22949521
Data identified RFC3 as a candidate oncogene amplified in esophageal adenocarcinoma (EAC). PMID: 22328562
RFC3 mutation and loss of RFC3 expression occur in large fractions of gastric and colorectal cancers and suggest that these alterations may contribute to the cancer pathogenesis by deregulating DNA repair and replication. PMID: 20573375

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Subcellular Location

Nucleus.

Protein Families

Activator 1 small subunits family

Database Links

HGNC: 9971

OMIM: 600405

KEGG: hsa:5983

STRING: 9606.ENSP00000369411

UniGene: Hs.115474

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

DNA repair pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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