RFK Antibody

Datasheet

Code	CSB-PA836167LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA836167LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA836167LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA836167LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RFK Polyclonal antibody

Uniprot No.

Q969G6

Target Names

RFK

Alternative Names

0610038L10Rik antibody; AF031381 antibody; ATP:riboflavin 5' phosphotransferase antibody; ATP:riboflavin 5''-phosphotransferase antibody; Flavokinase antibody; FLJ11149 antibody; KOI 4 antibody; Rfk antibody; Riboflavin kinase antibody; RIFK antibody; RIFK_HUMAN antibody; RP11-422N19.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Riboflavin kinase protein (1-154AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RFK Antibody (Product code: CSB-PA836167LA01HU) is Non-conjugated. For RFK Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836167LB01HU	RFK Antibody, HRP conjugated	ELISA
FITC	CSB-PA836167LC01HU	RFK Antibody, FITC conjugated
Biotin	CSB-PA836167LD01HU	RFK Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.

Gene References into Functions

Results from a study on gene expression variability markers in early-stage human embryos shows that RFK is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
DR4 and DR5 have a capability to activate Nox1 by recruiting RFK, resulting in ROS-mediated apoptotic cell death in tumor cells. PMID: 22158615
levels of riboflavin kinase expression correlate well with Gleason score, known as a good indicator of patient prognosis PMID: 21308351
the structure of riboflavin kinase cocrystallized with both MgADP and FMN is reported; drastic conformational changes associated with flavin binding are observed primarily at the so-called Flap I and Flap II loop regions PMID: 14580199
results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase PMID: 19641494

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Subcellular Location

Cytoplasm.

Tissue Specificity

Detected in brain, placenta and urinary bladder.

Database Links

HGNC: 30324

OMIM: 613010

KEGG: hsa:55312

STRING: 9606.ENSP00000365926

UniGene: Hs.37558

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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