RFK Antibody, Biotin conjugated

Datasheet

Code	CSB-PA836167LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RFK Polyclonal antibody

Uniprot No.

Q969G6

Target Names

RFK

Alternative Names

0610038L10Rik antibody; AF031381 antibody; ATP:riboflavin 5' phosphotransferase antibody; ATP:riboflavin 5''-phosphotransferase antibody; Flavokinase antibody; FLJ11149 antibody; KOI 4 antibody; Rfk antibody; Riboflavin kinase antibody; RIFK antibody; RIFK_HUMAN antibody; RP11-422N19.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Riboflavin kinase protein (1-154AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.

Gene References into Functions

Results from a study on gene expression variability markers in early-stage human embryos shows that RFK is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
DR4 and DR5 have a capability to activate Nox1 by recruiting RFK, resulting in ROS-mediated apoptotic cell death in tumor cells. PMID: 22158615
levels of riboflavin kinase expression correlate well with Gleason score, known as a good indicator of patient prognosis PMID: 21308351
the structure of riboflavin kinase cocrystallized with both MgADP and FMN is reported; drastic conformational changes associated with flavin binding are observed primarily at the so-called Flap I and Flap II loop regions PMID: 14580199
results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase PMID: 19641494

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Subcellular Location

Cytoplasm.

Tissue Specificity

Detected in brain, placenta and urinary bladder.

Database Links

HGNC: 30324

OMIM: 613010

KEGG: hsa:55312

STRING: 9606.ENSP00000365926

UniGene: Hs.37558

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Protein Service

Gene Synthesis Service

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Tag Antibodies, Your Good Partner in Protein Research Epitope Tags Overview Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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