RFK Antibody, HRP conjugated

Datasheet

Code	CSB-PA836167LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RFK Polyclonal antibody

Uniprot No.

Q969G6

Target Names

RFK

Alternative Names

0610038L10Rik antibody; AF031381 antibody; ATP:riboflavin 5' phosphotransferase antibody; ATP:riboflavin 5''-phosphotransferase antibody; Flavokinase antibody; FLJ11149 antibody; KOI 4 antibody; Rfk antibody; Riboflavin kinase antibody; RIFK antibody; RIFK_HUMAN antibody; RP11-422N19.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Riboflavin kinase protein (1-154AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.

Gene References into Functions

Results from a study on gene expression variability markers in early-stage human embryos shows that RFK is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
DR4 and DR5 have a capability to activate Nox1 by recruiting RFK, resulting in ROS-mediated apoptotic cell death in tumor cells. PMID: 22158615
levels of riboflavin kinase expression correlate well with Gleason score, known as a good indicator of patient prognosis PMID: 21308351
the structure of riboflavin kinase cocrystallized with both MgADP and FMN is reported; drastic conformational changes associated with flavin binding are observed primarily at the so-called Flap I and Flap II loop regions PMID: 14580199
results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase PMID: 19641494

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Subcellular Location

Cytoplasm.

Tissue Specificity

Detected in brain, placenta and urinary bladder.

Database Links

HGNC: 30324

OMIM: 613010

KEGG: hsa:55312

STRING: 9606.ENSP00000365926

UniGene: Hs.37558

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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