RGS20 Antibody

Datasheet

Code	CSB-PA019652GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O76081

Target Names

RGS20

Alternative Names

G(z)GAP antibody; Gz selective GTPase activating protein antibody; Gz-GAP antibody; Gz-selective GTPase-activating protein antibody; HGNC:14600 antibody; Regulator of G protein signaling 20 antibody; Regulator of G-protein signaling 20 antibody; Regulator of G-protein signaling Z1 antibody; Regulator of Gz selective protein signaling 1 antibody; Regulator of Gz-selective protein signaling 1 antibody; RGS20 antibody; RGS20_HUMAN antibody; RGSZ1 antibody; ZGAP1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human RGS20

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.

Gene References into Functions

NEAT1 silencing also inhibited tumor growth in vivo. Collectively, we revealed that the NEAT1/miR365/RGS20 axis may be a novel mechanism or therapeutic strategy for OSCC treatment. PMID: 29484420
Data suggest that Gpr176 (G-protein coupled receptor 176) is an SCN-(suprachiasmatic nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that sets the pace of circadian behavior; a unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176. [REVIEW] PMID: 28502923
These results suggest that the expression of RGS20 may promote metastasis of tumor cells. PMID: 27495875
Findings suggest that high regulator of G protein signaling 20 (RGS20) expression is associated with unfavorable survival in triple-negative breast cancer (TNBC). PMID: 28237701
provide new evidence that RGSZ1 interacts not only with Galpha(z,) but also with Galpha(i), as supported by in vitro binding assays and functional studies PMID: 12379657
NMR study PMID: 14872136
The major function of PKCI-1 is to modulate mu opioid receptor signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction. PMID: 17126529

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Subcellular Location

Membrane; Lipid-anchor. Nucleus. Cytoplasm.

Tissue Specificity

Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.

Database Links

HGNC: 14600

OMIM: 607193

KEGG: hsa:8601

STRING: 9606.ENSP00000297313

UniGene: Hs.368733

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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