RHOU Antibody, Biotin conjugated

1. These results unravel a role for RhoU not only in regulating the migratory features of malignant plasma cells, but also in controlling cell cycle progression. PMID: 29440639
2. This review addresses the developmental roles of 2 GTPases of the Rho family, RhoV/Chp and RhoU/Wrch. PMID: 26555387
3. PAK4 and RhoU cooperate to drive adhesion turnover and promote cell migration. PMID: 26598620
4. Data indicate that upregulated miR-126 upon coxsackievirus B3 (CVB3) infection targets SPRED1, LRP6, and WRCH1 genes, mediating cross-talk between ERK1/2 and Wnt/beta-catenin pathways, and thus promoting viral replication. PMID: 23811937
5. multiple upstream signals may converge on Wrch1 directly through its SH3 domain-binding properties PMID: 23183748
6. results indicate that NOTCH1 mutation stimulates T-cell acute lymphoblastic leukaemia cell migration through RhoU upregulation that could contribute to the leukaemia cell dissemination PMID: 22349824
7. data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio PMID: 21508312
8. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. PMID: 21565175
9. Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src. PMID: 20547754
10. Down regulation of WRCH1 by estradiol in breast cancer and altered expression of WRCH1 is associated with other cancers PMID: 11894124
11. G28K cDNA encodes a protein of 258 amino acids with homology to the cell division cycle 42/G25K protein; this gene is located at 1q42.11-q42.3; G28K was abundantly expressed in the stomach and the small intestine PMID: 14731133
12. These data suggest that Wrch-1 regulates cell migration by multiple mechanisms: on the one hand Wrch-1 controls focal adhesions by regulating myosin light chain and on the other hand Wrch-1 stimulates the activation of Akt and JNK. PMID: 17504809
13. Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of tight junction and actin organization. PMID: 19064640
14. As an essential actor of osteoclast differentiation, the atypical RhoGTPase Wrch1/RhoU could be an interesting target for the development of novel antiresorptive drugs. PMID: 19135548

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HGNC: 17794

OMIM: 606366

KEGG: hsa:58480

STRING: 9606.ENSP00000355652

UniGene: Hs.647774