RHOU Antibody

Code CSB-PA987503
Size US$166
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  • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse stomach and human fetal muscle tissue, Primary antibody: CSB-PA987503(RHOU Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Product Details

Uniprot No.
Target Names
RHOU
Alternative Names
ARHU antibody; CDC42 L1 antibody; CDC42 like GTPase antibody; CDC42-like GTPase 1 antibody; CDC42L1 antibody; G28K antibody; GTP binding protein like 1 antibody; GTP binding protein SB128 antibody; GTP-binding protein-like 1 antibody; hG28K antibody; mG28K antibody; Ras homolog gene family member U antibody; Ras homolog gene family member U isoform CRA a antibody; Ras like gene family member U antibody; Rho GTPase like protein ARHU antibody; Rho GTPase-like protein ARHU antibody; Rho related GTP binding protein RhoU antibody; Rho-related GTP-binding protein RhoU antibody; Rhou antibody; RHOU_HUMAN antibody; Ryu GTPase antibody; Wnt-1 responsive Cdc42 homolog 1 antibody; Wnt1 responsive Cdc42 homolog antibody; WRCH 1 antibody; WRCH-1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human RHOU
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Gene References into Functions
  1. These results unravel a role for RhoU not only in regulating the migratory features of malignant plasma cells, but also in controlling cell cycle progression. PMID: 29440639
  2. This review addresses the developmental roles of 2 GTPases of the Rho family, RhoV/Chp and RhoU/Wrch. PMID: 26555387
  3. PAK4 and RhoU cooperate to drive adhesion turnover and promote cell migration. PMID: 26598620
  4. Data indicate that upregulated miR-126 upon coxsackievirus B3 (CVB3) infection targets SPRED1, LRP6, and WRCH1 genes, mediating cross-talk between ERK1/2 and Wnt/beta-catenin pathways, and thus promoting viral replication. PMID: 23811937
  5. multiple upstream signals may converge on Wrch1 directly through its SH3 domain-binding properties PMID: 23183748
  6. results indicate that NOTCH1 mutation stimulates T-cell acute lymphoblastic leukaemia cell migration through RhoU upregulation that could contribute to the leukaemia cell dissemination PMID: 22349824
  7. data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio PMID: 21508312
  8. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. PMID: 21565175
  9. Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src. PMID: 20547754
  10. Down regulation of WRCH1 by estradiol in breast cancer and altered expression of WRCH1 is associated with other cancers PMID: 11894124
  11. G28K cDNA encodes a protein of 258 amino acids with homology to the cell division cycle 42/G25K protein; this gene is located at 1q42.11-q42.3; G28K was abundantly expressed in the stomach and the small intestine PMID: 14731133
  12. These data suggest that Wrch-1 regulates cell migration by multiple mechanisms: on the one hand Wrch-1 controls focal adhesions by regulating myosin light chain and on the other hand Wrch-1 stimulates the activation of Akt and JNK. PMID: 17504809
  13. Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of tight junction and actin organization. PMID: 19064640
  14. As an essential actor of osteoclast differentiation, the atypical RhoGTPase Wrch1/RhoU could be an interesting target for the development of novel antiresorptive drugs. PMID: 19135548

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Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome.
Protein Families
Small GTPase superfamily, Rho family
Tissue Specificity
Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
Database Links

HGNC: 17794

OMIM: 606366

KEGG: hsa:58480

STRING: 9606.ENSP00000355652

UniGene: Hs.647774

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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