RNASEH2C Antibody, FITC conjugated

Code CSB-PA837441LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RNASEH2C Polyclonal antibody
Uniprot No.
Target Names
RNASEH2C
Alternative Names
RNASEH2C antibody; AYP1 antibody; Ribonuclease H2 subunit C antibody; RNase H2 subunit C antibody; Aicardi-Goutieres syndrome 3 protein antibody; AGS3 antibody; RNase H1 small subunit antibody; Ribonuclease HI subunit C antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ribonuclease H2 subunit C protein (1-164AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Gene References into Functions
  1. This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2C in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
  2. Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the C subunit of RNase H2. PMID: 19015152
  3. Describes an RNASEH2C pseudogene that is located close to the SRY gene on chromosome Y. PMID: 8244390
Involvement in disease
Aicardi-Goutieres syndrome 3 (AGS3)
Subcellular Location
Nucleus.
Protein Families
RNase H2 subunit C family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 24116

OMIM: 610329

KEGG: hsa:84153

STRING: 9606.ENSP00000308193

UniGene: Hs.718438

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