RNF170 Antibody

Code CSB-PA019857GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RNF170
Alternative Names
RNF170; E3 ubiquitin-protein ligase RNF170; Putative LAG1-interacting protein; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RNF170
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
Gene References into Functions
  1. aberrant ubiquitination of substrates, or cellular adaptation to chronically reduced RNF170 levels likely accounts for the autosomal dominant sensory ataxia-associated Ca2+ signaling deficit PMID: 25882839
  2. RNF170 plays an essential role in IP(3) receptor processing via the ubiquitin-proteasome pathway. PMID: 21610068
  3. Together these results suggest that the mutation in RNF170 is causal for the sensory ataxia PMID: 21115467
Involvement in disease
Ataxia, sensory, 1, autosomal dominant (SNAX1)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in the spinal chord.
Database Links

HGNC: 25358

OMIM: 608984

KEGG: hsa:81790

STRING: 9606.ENSP00000434797

UniGene: Hs.491626

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