RNF26 Antibody

Code CSB-PA019883LA01HU
Size US$166
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Image
  • Western blot
    All lanes: RNF26 antibody at 6µg/ml + 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 48 kDa
    Observed band size: 48 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019883LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA019883LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA019883LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RNF26 Polyclonal antibody
Uniprot No.
Target Names
RNF26
Alternative Names
RNF26; E3 ubiquitin-protein ligase RNF26; RING finger protein 26
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase RNF26 protein (246-433AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RNF26 Antibody (Product code: CSB-PA019883LA01HU) is Non-conjugated. For RNF26 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA019883LB01HU RNF26 Antibody, HRP conjugated ELISA
FITC CSB-PA019883LC01HU RNF26 Antibody, FITC conjugated
Biotin CSB-PA019883LD01HU RNF26 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Gene References into Functions
  1. Study reveals the endoplasmic reticulum (ER)-located ubiquitin ligase Ring finger protein 26 (RNF26) as the global architect of the entire endosomal system, including the trans-Golgi network. PMID: 27368102
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity
Ubiquitous. Up-regulated in several cancer cell lines.
Database Links

HGNC: 14646

OMIM: 606130

KEGG: hsa:79102

UniGene: Hs.524084

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