RNF6 Antibody, Biotin conjugated

Code CSB-PA897080LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RNF6 Polyclonal antibody
Uniprot No.
Target Names
RNF6
Alternative Names
E3 ubiquitin-protein ligase RNF6 antibody; Ring finger protein (C3H2C3 type) 6 antibody; Ring finger protein 6 antibody; RING H2 protein antibody; RING H2 protein RNF6 antibody; RNF 6 antibody; RNF6 antibody; RNF6_HUMAN antibody; SPG2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase RNF6 protein (1-298AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Gene References into Functions
  1. High RNF6 expression is associated with breast cancer. PMID: 28223545
  2. This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia. PMID: 26971355
  3. Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics PMID: 16204183
  4. Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2, in human development. PMID: 18368307
  5. Functional anaylysis of the mouse homolog PMID: 11971979

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Involvement in disease
Esophageal cancer (ESCR)
Subcellular Location
Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body.
Protein Families
RNF12 family
Tissue Specificity
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
Database Links

HGNC: 10069

OMIM: 133239

KEGG: hsa:6049

STRING: 9606.ENSP00000342121

UniGene: Hs.136885

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