RNF6 Antibody, FITC conjugated

Datasheet

Code	CSB-PA897080LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RNF6 Polyclonal antibody

Uniprot No.

Q9Y252

Target Names

RNF6

Alternative Names

E3 ubiquitin-protein ligase RNF6 antibody; Ring finger protein (C3H2C3 type) 6 antibody; Ring finger protein 6 antibody; RING H2 protein antibody; RING H2 protein RNF6 antibody; RNF 6 antibody; RNF6 antibody; RNF6_HUMAN antibody; SPG2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human E3 ubiquitin-protein ligase RNF6 protein (1-298AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.

Gene References into Functions

High RNF6 expression is associated with breast cancer. PMID: 28223545
This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia. PMID: 26971355
Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics PMID: 16204183
Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2, in human development. PMID: 18368307
Functional anaylysis of the mouse homolog PMID: 11971979

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Involvement in disease

Esophageal cancer (ESCR)

Subcellular Location

Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body.

Protein Families

RNF12 family

Tissue Specificity

Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.

Database Links

HGNC: 10069

OMIM: 133239

KEGG: hsa:6049

STRING: 9606.ENSP00000342121

UniGene: Hs.136885

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Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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