RNMT Antibody

Datasheet

Code	CSB-PA019902GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O43148

Target Names

RNMT

Alternative Names

DKFZp686H1252 antibody; EC 2.1.1.56 antibody; hcm1p antibody; hCMT1 antibody; HCMT1a antibody; hCMT1c antibody; hMet antibody; hypothetical protein KIAA0396 antibody; KIAA0398 antibody; MCES_HUMAN antibody; MET antibody; mRNA (guanine 7)methyltransferase antibody; mRNA (guanine N(7)) methyltransferase antibody; mRNA (guanine-N(7)-)-methyltransferase antibody; mRNA cap guanine-N7 methyltransferase antibody; mRNA cap methyltransferase antibody; OTTHUMP00000162509 antibody; RG7MT1 antibody; RNA (guanine 7) methyltransferase antibody; RNA guanine 7 methyltransferase antibody; Rnmt antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human RNMT

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.

Gene References into Functions

Results identify a cytoplasmic pool of RNMT which is a component of the cytoplasmic capping complex, and demonstrate its function as the methyltransferase that catalyzes the final maturation step in cap homeostasis. PMID: 28981715
MYC promotes mRNA cap methylation and protein production of Wnt/beta-catenin signaling transcripts through recruitment of cyclin-dependent kinase 7 (CDK7) and consequently RNMT to gene promoters. PMID: 27899423
RNMT-RAM complex coordinates mRNA processing with ribosome production. PMID: 27934633
CDK1-Cyclin B1 activates RNMT, coordinating mRNA cap methylation with G1 phase transcription. PMID: 26942677
High RNMT expression is associated with liver cancer. PMID: 24763612
Data suggest the C-terminal nuclear localization domain (QYP) is critical for RAM (RNMT-activating mini protein) to enter the cell nucleus where RAM activates RNMT resulting in mRNA cap methylation. TNPO1/TNPO2 mediate RAM nuclear entry. PMID: 24200467
The RNMT N-terminal domain is required for transcript expression, translation and cell proliferation. PMID: 23863084
Nuclear localization of cap methyltransferase is mediated by alternative nuclear localization signal motifs PMID: 15767670

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Subcellular Location

Nucleus.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, mRNA cap 0 methyltransferase family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 10075

OMIM: 603514

KEGG: hsa:8731

STRING: 9606.ENSP00000262173

UniGene: Hs.592347

Promotions

Transmembrane Protein Questionnaire with Gifts

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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