Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ROBO2 Polyclonal antibody

Uniprot No.

Q9HCK4

Target Names

ROBO2

Alternative Names

lea antibody; Robo 2 antibody; Robo2 antibody; ROBO2_HUMAN antibody; Roundabout 2 antibody; Roundabout homolog 2 antibody; roundabout, axon guidance receptor, homolog 2 (Drosophila) antibody; Roundabout2 antibody; SAX 3 antibody; SAX3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Roundabout homolog 2 protein (450-660AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function	Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
Gene References into Functions	determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4 PMID: 29017837 ROBO2 variants were not found to be associated with nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia, providing further evidence for genetic heterogeneity PMID: 27002985 ROBO2 and RASSF2A gene methylations may be related to gastric tumorigenesis, and ROBO2 gene methylation is associated with sporadic gastric cancer. PMID: 27461616 Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer PMID: 26542734 ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired. PMID: 26608094 Common variation near ROBO2 is associated with expressive vocabulary in infancy. PMID: 25226531 Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract PMID: 26026792 Down-regulation of ROBO2 expression is associated with prostate cancers. PMID: 24272677 The finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy. PMID: 23982283 Results not completely rule out that some ROBO2 variants may be the sole cause of vesicoureteric reflux, but it is clear from the overall frequency that most of them cannot be. PMID: 23536131 two differentially expressed isoforms were isolated and identified. Exons 1 and 2 of human ROBO2a lie in an inherently unstable DNA segment at human chromosome 3p12.3. PMID: 16829019 Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. PMID: 17357069 a relatively high frequency of ROBO2 variants (5.1%) was found in familial vesicoureteral reflux PMID: 18235093 mRNA expression of ROBO2 in lymphocytes was significantly reduced in the autistic group PMID: 18270976 gene variants in ROBO2 are rare causes of VUR in humans. Our results provide further evidence for the genetic heterogeneity of this disorder PMID: 19350278 Show More Hide All
Involvement in disease	Vesicoureteral reflux 2 (VUR2)
Subcellular Location	Membrane; Single-pass type I membrane protein.
Protein Families	Immunoglobulin superfamily, ROBO family
Database Links	HGNC: 10250 OMIM: 602431 KEGG: hsa:6092 STRING: 9606.ENSP00000417335 UniGene: Hs.13305

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Check Code：

Code	CSB-PA888028ESR1HU
Size	US$299
Image	Western Blot Positive WB detected in: SH-SY5Y whole cell lysate, Ntera-2 whole cell lysate All lanes: ROBO2 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 131, 152, 154 kDa Observed band size: 152 kDa
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ROBO2 Antibody

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Target Background

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