ROBO2

ROBO2 encodes the Roundabout guidance receptor 2 protein, also commonly known as AXIN-1-binding protein. This single - pass type I membrane protein plays a key role in axon guidance and neural development. It functions by binding to its ligand, Slit, which inhibits axon attraction and promotes repulsion. Involved in the Slit - ROBO signaling pathway, it also affects cell migration and angiogenesis.
Abnormal expression of ROBO2 is associated with various diseases, such as some forms of cancer and neurological disorders. In drug development, researchers are exploring small - molecule inhibitors targeting ROBO2 - Slit interaction, aiming to regulate its function and develop new therapies for related diseases.