RPIA Antibody

Datasheet

Code	CSB-PA020104LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HepG2 whole cell lysate, K562 whole cell lysate, U251 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate All lanes: RPIA antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34 kDa Observed band size: 33 kDa IHC image of CSB-PA020104LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RPIA Polyclonal antibody

Uniprot No.

P49247

Target Names

RPIA

Alternative Names

EC 5.3.1.6 antibody; MGC103524 antibody; Phosphoriboisomerase A antibody; Phosphoriboisomerase antibody; Ribose 5 phosphate isomerase antibody; ribose 5-phosphate epimerase antibody; ribose 5-phosphate isomerase A antibody; Ribose-5-phosphate isomerase antibody; RPI antibody; rpiA antibody; RPIA_HUMAN antibody; zgc:103524 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ribose-5-phosphate isomerase protein (1-311AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RPIA Antibody (Product code: CSB-PA020104LA01HU) is Non-conjugated. For RPIA Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA020104LB01HU	RPIA Antibody, HRP conjugated	ELISA
FITC	CSB-PA020104LC01HU	RPIA Antibody, FITC conjugated
Biotin	CSB-PA020104LD01HU	RPIA Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Antigen Affinity purified & Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
IHC	IHC;WB:1:1000-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Gene References into Functions

The results are consistent with a model in which RPIA suppresses autophagy and LC3 processing by modulation of redox signaling. PMID: 27328773
CRC cells that overexpressed miR124 or with knockdown of RPIA or PRPS1 had reduced DNA synthesis and proliferation, whereas cells incubated with an inhibitor of miR124 had significantly increased DNA synthesis and proliferation and formed more colonies. PMID: 26248089
In this work, through an in silico comparative analysis between the genomes of Leishmania major and Homo sapiens, the enzyme ribose 5-phosphate isomerase (R5PI) was indicated as a promising molecular target. PMID: 25528729
Study provides new insight into the molecular mechanisms by which RPIA overexpression can induce oncogenesis in hepatocellular carcinoma. PMID: 25429733
RPI is the second known inborn error in the reversible phase of the pentose-phosphate-pathway, confirming that defects in pentose and polyol metabolism constitute a new area of inborn metabolic disorders PMID: 14988808

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Involvement in disease

Ribose 5-phosphate isomerase deficiency (RPID)

Protein Families

Ribose 5-phosphate isomerase family

Database Links

HGNC: 10297

OMIM: 180430

KEGG: hsa:22934

STRING: 9606.ENSP00000283646

UniGene: Hs.469264

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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