RTKN Antibody

1. Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer. PMID: 27498032
2. RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. PMID: 27922690
3. The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery. PMID: 26935528
4. RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2/3/5, CDK1/2 and PCNA PMID: 26349972
5. suggest that interaction of S100A4 and Rhotekin permits S100A4 to complex with RhoA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea PMID: 22964635
6. Rho/RTKN-mediated NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis. PMID: 15316142
7. overexpression may play a key role in gastric tumorigenesis by conferring cells resistance to apoptosis PMID: 15480428
8. These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy. PMID: 15599595
9. Lin-7B is a binding partner for Rhotekin in the human brain cDNA library PMID: 16979770
10. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling PMID: 17546647
11. Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487
12. Loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN. PMID: 19360360

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HGNC: 10466

OMIM: 602288

KEGG: hsa:6242

STRING: 9606.ENSP00000272430

UniGene: Hs.192854